First of all water is pretty safe, obviously. However, watercolors will eventually stain the surface - as they do with anything else. So here is the result of exposure to several, and some rather nasty, chemicals that artists might use. Needless to say nothing we tried had any effect. Below is the list.
From top to bottom:
Denatured Alcohol - right out of the can.
Paint Thinner - The regular stuff you get at the hardware store.
Toluene - A standard thinner for oil-based paints.
MEK Methyl Ethyl Keytone - Pretty nasty stuff used to thin and remove resins used for fiberglass.
Naptha - A common cleaner and spot remover derived from natual gas.
Acetone - Another particularly nasty chemical, fingernail polish remover.
Lacquer Thinner - used to dilute oil-based lacquers and paints.
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